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KMID : 1007520100190061667
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Food Science and Biotechnology
2010 Volume.19 No. 6 p.1667 ~ p.1671
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Anti-photoaging Effects of 2-Methoxy-5-(2-methyl propyl) Pyrazine Isolated from Peach (Prunus persica (L.) Batsch)
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Han Sung-hwa
Park Kwang-Kyun
Chung Won-Yoon
Lee Sang-Kook
Kim Jae-kyung
Hwang Jae-Kwan
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Abstract
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In this study, antioxidant and anti-photoaging activities of 2-methoxy-5-(2-methyl propyl) pyrazine (MMPP) isolated from peach (Prunus persica (L.) Batsch) were investigated in terms of matrix metalloproteinase (MMP)-1 and type-1 procollagen expression in ultraviolet (UV)-irradiated human skin fibroblasts. MMPP was obtained from the butanol fraction of a 95% ethanol extract of peach. The antioxidant and anti-photoaging activity of MMPP were assessed by 1,1-diphenyl-2-picrylhydrazy (DPPH), Western blot, and reverse trans-cription-polymerase chain reaction (RT-PCR) analyses. MMPP displayed radical scavenging activity, suppressed MMP-1 expression, and increased type-1 procollagen expression. These results support the use of MMPP from peach as an antiphotoaging compound.
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KEYWORD
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photoaging, 2-methoxy-5-(2-methyl propyl) pyrazine, matrix metalloproteinase-1, type-1 procollagen
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